Study on the Pharmacological Effect of Guliao Bone

Pharmacological study

1. According to Zhou Chushui et al. of the China Pharmaceutical University, gavage of rhizome (20 g/kg, 30 g/kg) and pomelo peel (20 g/kg) was effective in promoting bone healing in experimental rats.

2. The decoction of crushed minced water decoction 7.5-50g/kg gavage can stimulate the compensatory proliferation of osteochondral chondrocytes in rat experimental arthritis, and can partially improve the degenerative changes of articular cartilage due to changes in mechanical stress lines. Reduce the rate of osteoarticular lesions.

3. Rhizoma Drynaria dihydroflavone can increase the beating frequency of cultured rat cardiomyocytes in vitro, make the contraction strong, and have a pacing effect on cardiomyocytes. Its mechanism of action may be similar to a β-agonist.

4. Decoction water decoction (100%) 0.8ml/kg orally, can significantly prevent the rise of serum cholesterol, triglyceride, and prevent the formation of atherosclerotic plaque in experimental aortic hyperlipidemic rabbits.

5. The guinea pig experiments suggest that the combination of Gusuibu decoction and kanamycin can reduce the toxicity of kanamycin to the cochlea, but it cannot control the development of toxic deafness after discontinuation.

6. Decoction decoction can inhibit the growth of staphylococci in vitro.

Decoction of Rhizoma Drynariae 7.5,10,25,50g/kg orally, has a certain function of improving chondrocytes, delaying cell degenerative changes, and reducing the rate of osteoarthritis in rat osteoarthritis model, with the dose Increased, increased effects, and better after two months of administration. 100g (crude drug)/kg/day of Rhizoma Drynaria decoction taken orally 2 hours before kanamycin, for 8 consecutive days, can reduce the toxicity of kanamycin to the cochlea, but cannot control the development of toxic deafness after discontinuation .

【Taste】

Bitter, warm.

1 "Japan Hanako Materia Medica": "Ping."

2 "Kaibao Materia Medica": "Bitter, warm, non-toxic."

3 "Guangxi Herbal Medicine": "Gan slightly bitter, warm."

【Practical】Into the liver and kidney.

1 "Outline": "Foot Shaoyin."

2 "Bencai seeking truth": "Into the kidney, and into the heart."

3 "Bencao again new": "into the liver, kidney two classics."


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