ã€Pharmacological effects】
1. The role of the digestive system
The effect on the smooth muscles of isolated intestine: A rat, guinea pig or rabbit small intestine was placed in a bench fluid bath and recorded by the recorder to record the changes in intestinal activity, and the effect of the liquid on the spontaneous activity of the intestine was observed, and the effect of acetylcholine and BaCl2 was antagonized. Results In the case of yangchun sand decoction (2.5-5×10(-3)g crude drug/ml), guinea pigs and rat small bowel intestine can be intensified. When the dose is increased, the intestinal tract can be inhibited, and the tension is reduced and the amplitude is reduced. Yangchun sand decoction partially inhibited the tension and tonic contraction of rat small bowel caused by acetylcholine and barium chloride. The volatile parts of Yangchun sand (1.3×10(-3)g crude drug/ml) can slightly stimulate the intestinal tract in rabbits, and then transfer to a significant inhibitory effect. The tension decreases, the contraction frequency decreases, and the amplitude decreases. Or completely antagonize acetylcholine, BaCl2 induced bowel excitement or paralysis.
Effects on intestinal motility: Mouse body weight (20-24g) was randomly divided into 2 groups. The administration group was given decoction (0.5g/kg). The control group was given distilled water and the charcoal was calculated to reach the intestine. The length/percentage of the entire intestine to measure the functional status of bowel propulsion. Results The administration group was 82.2±4.4% compared with the control group (62.5±2.9) P<0.01, indicating that Amomum villosum can promote intestinal movement.
2. Effect on platelet aggregation
The weight of rabbits (2.0-2.6 kg) was 3-4 mice in each group. The dose groups were two dose groups, and the mice were orally administered with 0.6 and 1.2 g/kg of Amomum villosum respectively. The control group received the same dose of solvent orally. After 15 minutes, 60 minutes and 90 minutes after administration, blood was collected from the carotid artery and centrifuged to prepare PRP and PPP. Platelet aggregation rate (%) was measured on the platelet aggregation apparatus using ADP as a polymerization agent. The results showed that Amomum can obviously inhibit platelet aggregation.
3. Antiulcer effect
Amomum 0.3g/Kg, 0.6g/Kg, 1.2g/kg by gavage, significantly inhibited the stress ulcer in mice bound with water immersion; 0.6g/kg gavage, can significantly reduce the rat's Gastric fluid secretion; Test tube experiments show that Amomum can significantly inhibit gastric protein digestion.
4. Effect of arachidonic acid-induced acute death in mice
Mice (weight 20-22 g) were divided into 10 groups. The two groups were orally administered with 0.6 and 1.2 g/kg of Amomum villosum and the control group was orally dosed with an equal volume of solvent. Intravenous arachidonic acid was administered 1.5 hours after administration and the mice were observed dead within 15 minutes. Results Two and one mice died at doses of 0.6 and 1.2 g/kg, respectively. Compared with the control group (7 deaths), all had a P<0.001, indicating that arachidonic acid induced acute death in mice. There is obvious protection.
5. Effect of Mixture of Collagen and Epinephrine on Death of Mice
Mice (20-22 g body weight) were divided into groups of 10 mice. The two treatment groups were administered gavage with 0.6 and 1.2 g/kg of Amomum villosum. The control group was given an equal volume of solvent. After 1.5 hours, the mice were injected with a mixture of collagen and epinephrine intravenously. The mice were observed for death within 15 minutes. Results 3 and 2 mice died in the large and small dose groups, respectively, compared with the control group (8 deaths), P<0.05 and P<0.01, indicating that Amomum villosum had apparent resistance to collagen and epinephrine induced The role of acute death in mice.
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