Release date: 2015-02-04
Microchip physical map (size to 1 euro coin)
The Fraunhofer Institute for Applied Research and Development (the largest applied scientific research institute in Europe) recently stated that they have developed a very promising micro-biochip that can realistically simulate complex metabolic processes in the human body and may be in the future. The animal model was completely replaced in the experiment.
In order to confirm the effectiveness of drugs, animals have always been an indispensable experimental model in the laboratory, because it is not enough to test the effects of a substance in a single tissue or cell. Assessing the role of drugs in the body is evaluated from the perspective of overall impact. The toxic substances produced by the metabolic process may affect other organs. But the problem is that animal reactions do not fully represent the human body.
Researchers from the Institute of Biotechnology at the Technical University of Berlin and the Dresden-based Institute have jointly designed a new solution – a multi-organ chip that replicates the complexities of the human body with amazing accuracy. Metabolic process. The researchers said they replicated the human body's structure in a ratio of 1:100,000: the cells of various organs are located at different locations within the chip, and these "micro-organs" are connected to each other by small pipes. A micropump continues to transport liquid cell culture fluid through the microchannels to simulate the body's blood circulation system. One of the great advantages of this chip is that researchers can modify the structure of the chip as needed, such as the number of "organs", the connection state with the microchannels, and simulate different pathologies or physiological states. This technology can be applied not only to the detection of active ingredients in new drugs, but also to the testing of skin tolerance for new cosmetics.
The concept of a practical fluid channel connecting different types of cell samples is not new, but this new technology has several distinct advantages over the same: professional engineering allows the micropump to maintain a pipe flow rate of less than 0.5 microliters per second. This ratio is the best way to simulate the relationship between cells and liquid media. Second, the microfluidic system within the chip ensures a constant, continuous flow state, as is human blood, which is important.
Researchers have loaded cells on the chip and tested the effects of related substances, and they have clearly detected the effects of metabolites and other cells produced in specific cells. It can be said that this technique is more convincing than testing drugs on animal models, because the animal's body reaction cannot be restored to human body 1:1.
This technology has been put into use in some cosmetics industries. Perhaps in the near future, microchips will also be applied to the field of drug research.
Source: Bio Valley
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