With the introduction of the new "Environmental Protection Law" and the new "Food Safety Law" in 2015, and the increasing public attention to food safety, the state has increased supervision in environmental protection and food safety, and the Ministry of Agriculture has also introduced one. Series antibiotic products are banned. Some companies are in a difficult position under this situation. Therefore, according to the current national form policy, “feed ban†is an inevitable trend of China's future animal husbandry development, and it is also an irreversible trend of the times. Therefore, green, environmental protection, non-resistance, and ecological farming have become the new direction of future development.
How to choose "no resistance, resistance" in the post-antibiotic era?
At present, the impact of environmental protection is continuing and spreading. In the face of increasingly strict restrictions on the use of antibiotics, antibiotic substitutes have mushroomed. At present, it is mainly represented by microecological preparations, enzyme preparations, antibacterial peptides, acidifiers, essential oil extracts and traditional Chinese medicines. However, these antibiotic alternatives still have some limitations in the specific use process. For example, the standardization and differentiation of microecological preparations are obviously insufficient; the enzyme preparations do not achieve the effect of antibiotics; the antibacterial peptides are widely available, many types, small molecular mass, low in natural content, difficult to separate and purify, high in chemical synthesis cost; acidifier The amount of addition is large and the cost is high; while some essential oil extracts are chemically synthesized; some Chinese herbal medicine extracts have a shortage of resources, unstable drug efficacy and quality, high cost, rough processing, complicated formula, and Chinese medicine for national standards. The detection methods of the products are too singular. In the latest batch of fake veterinary drugs notified by the Ministry of Agriculture, the Chinese veterinary drugs have become the hardest hit areas for counterfeit drugs. In combination with China's current national conditions, we still have a long way to go to the road of no resistance, but this is only a process.
Starting from the development of the feed industry and the requirements of green farming, Shandong Longchang Animal Health Products Co., Ltd. uses the modern advanced extraction process to produce pure natural Eucommia leaf extract (Happiness 100), which is certified by the national green feed ingredients. The main components are chlorogenic acid ≥ 5%; Eucommia polysaccharide ≥ 20%; Eucommia flavonoids ≥ 8%. Through a large number of experiments, it has been proved that the extract of Eucommia ulmoides leaves has the functions of “antibacterial, anti-viral, anti-oxidation and anti-oxidationâ€, and can promote the rapid growth of livestock and poultry, improve its production performance, replace antibiotics, and reduce the cost of feed.
Eucommia leaf extract substitute for antibiotic test
Application of Eucommia ulmoides Leaf Extract in Pigs
1. Effect of Eucommia ulmoides leaf extract replacing antibiotics on growth performance of weaned piglets
Taking Du Changda ternary crossbred piglets as the object, observe the effect of Eucommia ulmoides leaf extract instead of antibiotics on the performance of weaned piglets. A total of 160 weaned piglets were selected for testing and divided into 2 treatment groups with 4 replicates in each group and 20 piglets per replicate. The basal diets of the control group and the experimental group were the same, the antibiotics were added to the control group, and the experimental group was supplemented with 250 mg/kg of Eucommia ulmoides leaf extract instead of antibiotics.
Test design
Comparison of production performance of weaned piglets
Note: Different data in the same column indicates significant difference (p<0.05)
The results showed that compared with the control group, the daily weight gain of the experimental group increased by 5%, the feed-to-meat ratio decreased by 5%, the daily feed intake did not change significantly, the cost of meat production decreased by 0.26 yuan/kg, and the diarrhea rate decreased. Therefore, the use of Eucommia ulmoides leaf extract to replace antibiotics in weaned piglets diet is not only feasible, but also can improve the performance of piglets, reduce the cost of meat production, protect intestinal health, and reduce the incidence of intestinal diseases such as diarrhea.
2. Effect of Eucommia ulmoides leaf extract replacing antibiotics on growth performance of growing and finishing pigs
March 24th - May 16th, 2016, a total of 53 days.
Sixty healthy growth and finishing pigs with self-cultivation and close weight (about 75 kg) were randomly divided into control group and experimental group, with 3 replicates in each group and 10 replicates in each group. The control group was fed a basal diet, 50% of the coated guitarmycin was added to the diet, and 150 ppm of Eucommia leaf extract was added to the test group to remove the guitarmycin.
Test data summary table
It can be seen from the above table that after 53 days of feeding test, compared with the control group, the daily weight gain of the test group increased by 8.73%; the daily feed intake increased by 5.98%; the feed-to-meat ratio decreased by 2.69%; the cost per kilogram of meat was reduced. 0.21 yuan. Therefore, in the growth and finishing pig feed, not only the extract of Eucommia ulmoides leaves can replace the guitarmycin, but also can improve the growth performance, reduce the cost of meat production and increase economic benefits.
Effects of extracts of Eucommia ulmoides leaves on immune function and antioxidant function in piglets
The extract of Eucommia ulmoides leaves was added to the basal diet to observe the effect on the immune function of the piglets. 60 weaned piglets with the same body weight of 10kg and the same variety (Du Changda ternary cross) were randomly divided into the control group and the experimental group according to the principle of the same sex ratio and the same genetic background. Each group had 3 replicates, each Repeat 10 heads, the control group was fed the basal diet (with chlortetracycline), the test group was added 150g/t Eucommia leaf extract, the pre-test period was 7d, and then entered the 50-day trial period.
Effect on immune function of piglets
As can be seen from the above table, IgG concentration, IgM concentration and IgA concentration were increased by 15.51%, 8.93% and 8.66%, respectively, and the control group was significantly different from the test group (p<0.05). It is indicated that the addition of Eucommia ulmoides leaf extract can enhance the humoral immune function of piglets and enhance the body's resistance to disease.
Effect on antioxidant function of piglets
As can be seen from the above table, compared with the control group, the activities of SOD and GSH-Px increased by 20.29% and 31.06%, respectively, and the concentration of MDA decreased by 33.46%, and the difference between the control group and the experimental group was significant (p<0.05). . It indicated that Eucommia ulmoides leaf extract can improve the antioxidant capacity of piglets, relieve oxidative stress, and provide a relatively stable internal environment for piglet growth and development.
4. Effect of Eucommia ulmoides leaf extract replacing antibiotics on reproductive performance, litter size and weaning of sows
Select 100 healthy and lively pregnant 77-day-old pregnant sows with the same parity or parity, and divide the pregnant sow into the control group and the experimental group according to the principle of similar weight, sex and parity. Each group 5- 8 heads, no repetition. The control group was fed the basal diet, and the experimental group was fed the basal diet + 200 g/t Eucommia leaf extract. The diets of each test group were powdered, and the diet formula and nutrition level of each group were the same. The pre-test period is 7 days, 77-84 days is the pre-test period; 84 days--the end is the trial period, and the experiment is continued until the piglets are weaned.
Effect of Eucommia ulmoides Leaf Extract on Litter Birth
From the analysis of sows' litter size, the average litter size, average live litter weight and life head weight of the experimental group were higher than those of the control group.
Effect of Eucommia ulmoides Leaf Extract on Weaning of Piglets
From the weaning weight gain of the piglets, the weaning weight of the test group was only 6.26 kg, and the weaning weight of the control group was only 5.67 kg. The variance analysis showed that the difference was extremely significant (p<0.01).
Effect of extract of Eucommia ulmoides leaves on estrus in sows
For the estrus situation of the sow, the estrus rate of the test group was significantly higher than that of the control group; the average estrus interval in the test group was 5.69 days, and the control group was 5.71 days, which was shortened in estrus time.
Application of Eucommia ulmoides Leaf Extract in Broiler
1. Effect of Eucommia ulmoides leaf extract replacing antibiotics on growth performance of yellow feather broilers
This study investigated the effect of Eucommia ulmoides leaf extract instead of antibiotics on the growth performance of yellow feather broilers. 800 one-day-old healthy Lingnan yellow fast large yellow feather broilers were randomly divided into 8 groups, with 4 replicates in each group and 25 replicates in each group. The test period is 50 days. The control group was fed the basal diet. The test group 1 , the test 2 group, the test 3 group, the test 4 group, and the test 5 group were the experimental groups. The fed diets were supplemented with different gradients of Eucommia extract or antibiotics.
Experimental design of the effect of Eucommia ulmoides Oliv. leaf extract on the performance of fast large yellow broilers
Note: Antibiotics = Sulfuric Acid Antibiotics 150mg/kg + Nasitide 200mg/kg
results and analysis:
During the test, the broilers were in good health. Before the age of 20 days, 1-2 died in each group, mainly because the chicks were too crowded to die. 21-50 days old due to excessive temperature, excessive heat stress caused death, each group died. There was no significant difference between the two groups (P>0.05). It can be seen from the above table that from the 1-50 day old test, the average daily feed intake in group IV and V was significantly higher than that in the control group and all the experimental groups (P<0.05), and the VI group was significantly higher than the control group and group II. (P<0.05). The weight-to-weight ratio was not significantly different between the control group and the control group (P>0.05), and the other test groups were significantly lower than the control group and the second group.
in conclusion:
1 Adding 300mg/kg of Eucommia ulmoides extract has the best effect on improving the performance of broilers.
2 The addition of 100 mg/kg of Eucommia ulmoides extract and sulphate antibiotics and nosiheptide to improve broiler performance performance is almost equivalent to 1.
3 Eucommia extract has an effect on relieving heat stress in broilers and increasing feed intake.
4 Adding 300g/mg Eucommia extract can replace the combination of antibiotic sulfate antibiotics 150mg/kg and nosiheptide 200mg/kg.
After a lot of experimental practice, the extract of Eucommia ulmoides leaves is a new type of feed additive with “stable, high-efficiency, green, safe, non-polluting and no residueâ€; Eucommia ulmoides leaf extract is a wise choice for antibiotic substitutes; Eucommia ulmoides leaf extract The use of the non-resistance, ecological, green and healthy farming requirements advocated by the countries in the world today; the extract of Eucommia ulmoides leaves is the harmonious straight train of the animal husbandry to the new era of “feed no resistanceâ€!
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