Japanese islet transplantation for diabetes breakthrough
March 14, 2018 Source: Xinhuanet
Window._bd_share_config={ "common":{ "bdSnsKey":{ },"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":" 0","bdSize":"16"},"share":{ }};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')) .src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)];The Japan Institute of Physical Chemistry and Fukuoka University have announced a new study. Their researchers have found through animal experiments that subcutaneous adipose tissue at the thigh root is a suitable site for subcutaneous transplantation of islets and is expected to become a new treatment for diabetes.
In the past, islet transplantation for the treatment of diabetes is mainly to transplant islet cells into the liver of patients, but this transplantation method is prone to early rejection reaction, and it will be difficult to remove the transplanted cells in case of problems, and several transplants are required. Although there have been studies of subcutaneous transplantation of islet cells, the survival rate of islet cells after transplantation is extremely low.
The new study found that the previous subcutaneous transplantation of islets often caused insufficient blood flow to survive the islet cells due to insufficient subcutaneous blood vessels. Most of the subcutaneous transplanted islet cells died. The treatment of a diabetic mouse requires islet cells of five or six experimental mice.
Therefore, the researchers tried to find a place with adequate blood flow under the skin, and finally found that the subcutaneous adipose tissue at the root of the thigh is a site suitable for subcutaneous transplantation of the islets, because this part of the blood flow is sufficient. In the experiment, the researchers transplanted islet cells into the subcutaneous adipose tissue of the thigh root of the experimental rats with diabetes, and only a small amount of islet cells successfully cured the diabetes of the rats.
According to the researchers, humans and experimental rats have the same subcutaneous fat tissue in anatomy, so it can be considered that the same therapeutic effect can be produced in humans. This new transplantation method overcomes many of the problems of previous transplantation techniques and is expected to become a new method for treating diabetes.
The results of this research have been published in the American Journal of Transplantation. (Reporter Huayi)
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