TSQ Triple Quadrupole Mass Spectrometer Concise Application Manual - Food Safety Testing

TSQ Triple Quadrupole Mass Spectrometer Concise Application Manual - Food Safety Testing

Service Science, the world's leading - Thermo Fisher Scientific

Thermo Fisher Scientific (NYSE: TMO) is the world leader in scientific services. The company has annual sales of $17 billion and employs approximately 50,000 people in 50 countries. Our mission is to help our customers make the world healthier, cleaner and safer. Our products and services help customers accelerate research in the life sciences, solve complex problems and challenges in the field of analytics, promote medical diagnostics, and increase laboratory productivity. With four leading brands, Thermo Scientific, Life Technologies, Fisher Scientific, and UnityTM Lab Services, we combine innovative technology, convenient procurement solutions, and total solution for laboratory operations management to create value for customers, shareholders, and employees. For more information, please visit the company's website:

Thermo Fisher Scientific China

Thermo Fisher Scientific has been in China for more than 30 years, with its headquarters in Shanghai, and branches in Beijing, Guangzhou, Hong Kong, Taiwan, Chengdu, Shenyang, Xi'an, Nanjing, Wuhan, etc. 3,800. To meet the needs of the Chinese market, eight existing plants operate in Shanghai, Beijing and Suzhou. We have established 6 application development centers in Beijing and Shanghai to bring world-class cutting-edge technologies and products to domestic customers and provide application development and training services. The China Innovation Center in Shanghai combines the needs of the domestic market with Advanced foreign technology, research and development of China's technology and products; we have a nationwide maintenance service network and a specially established Chinese technical training team, with more than 2,000 engineers throughout the country to provide after-sales service. We are committed to helping our customers make the world healthier, cleaner and safer. For more information, please visit

Thermo Scientific Brand Life Science Mass Spectrometry

Formerly known as the mass spectrometer pioneer - the United States Finnigan mass spectrometer manufacturer. For fifty years since its inception in 1967, Finnigan Mass Spectrometry has maintained its world-leading position in mass spectrometry with unparalleled research and has the most comprehensive line of mass spectrometry products. Thermo Scientific's patented 3 mass analyzer technology: conjugate hyperbolic quadrupole for perfect theoretical electric field, linear ion trap (LTQ) for quantitative characterization, and ultra-high resolution electrostatic field orbital trap (Orbitrap) ). Thermo Scientific chromatography and mass spectrometry products have been in China for more than 20 years and have grown with China in the reform and opening up. It has branches in Beijing, Shanghai and Guangzhou, and has developed and established an organizational structure centered on customer needs. The business covers China and Hong Kong, and has positive recognition and support from customers. Active research cooperation with Chinese research units in the fields of environmental protection, agriculture, public security, commodity inspection, petroleum, chemical, geological, quarantine, pharmaceutical, health, nuclear science and other fields.

Thermo Scientific Life Science and Technology Mass Spectrometry's long history of technology

1967 Finnigan was founded in Palo Alto, California, USA

1968 The world's first quadrupole GC/MS (Model 1015) for Stanford University

1970 Introduced chemical ionization source

1971 The world's first intelligent GC/MS/DS for the US Environmental Protection Agency (EPA)

1976 The most successful mass spectrometer in history, with the introduction of the 4000 Series GC/MS and INCOSTMMS data systems

1977 Launches the world's first commercial LC/MS

1978 Developed a patented pulsed positive and negative ion chemical ionization source; introduced the world's first quantitative capillary GC equipped with a cold on-column injector

1979 OWA® (Inorganic Organics) GC/MS Analyzer

1980 Launched the world's first triple quadrupole MS/MS (TSQ ® ) mass spectrometer

1981 MAT is the world's leading manufacturer of organic magnetic mass spectrometers and gas isotope mass spectrometers. Finnigan merged with it and renamed Finnigan

MAT company. Production of high sensitivity, high accuracy and high precision gas isotope ratio mass spectrometer (Model 251/261)

1982 Launched low-cost, compact Delta series isotope ratio MS

1983 Launch of patented ion trap DetectorTM (ITDTM) and thermal spray LC/MS interface

1986 Introduces the all-digital triple quadrupole mass spectrometer (TSQ ® 70 ) and magnetic mass spectrometer ( MAT 90 )

1989 LDC/Milton Roy was acquired by Thermo Electron. ESI source as an interface to LC/MS for TSQ® 70 mass spectrometer

1990 Finnigan MAT acquired by Thermo Electron

1991 Launched the world's first MALDI/TOF (LASERMATTM)

1993 Spectra-Physics Analytical acquired by Thermo Electron

1995 Finnigan Introduces GCQTM and LCQTM Benchtop Ion Trap Mass Spectrometers; Launches ELEMENT, High Resolution Magnetic ICP/MS

1997 Introduced the TraceTM GC and GC/MS Multi-Injector/Multi-Detector Capillary System; AQATM Benchtop Quadrupole LC/MS. Introduces XcaliburTM MS control and data processing software that is fully compatible with MSn data systems

1999 Introduced LCQTM DUO and LCQTM DECA ion trap mass spectrometer; TRITON TI isotope ratio MS

2000 introduced TEMPUSTM ultra-fast GC/TOF-MS; NEPTUNE multi-receiver high-resolution ICP-MS;

SurveyorTM HPLC for LC/MSn; Polaris QTM EI/ CI GC/MS/M

2001 Launched the world's first high-resolution, ultra-small benchtop triple quadrupole mass spectrometer TSQ Quantum

2001 Introduced the third generation ion trap mass spectrometer LCQTM Advantage and LCQTM DECA XP

2002 Introduced the world's smallest liquid-mass spectrometer Surveyor-MSQ, higher sensitivity LCQTM DECA XP plus, the leading fifth-generation GC/MS Trace

DSQTM, ultra-fast gas chromatography FastGC, Focus GC and high-throughput proteomics research platform ProteomeX

2003 Introduced Linear Ion Trap - High Resolution Fourier Cyclotron Resonance Mass Spectrometry LTQ FTTM MS, Precision Mass High Resolution Triple Quadrupole Mass Spectrometry TSQ Quantum Ultra AM and Linear Ion Trap Mass Spectrometry LTQTM

2004 Introduced the single-channel GC/MS, the second-generation Proteome X LTQ, the TSQ Quantum Discovery MAX, and the vMALDI source. Introduced the MSQ Plus single-stage quadrupole mass spectrometry system. Introduced LCQTM Advantage MAX and LCQTM DECA XP MAX

2005 Introduced LTQ Orbitrap, a next-generation instrument that combines accurate mass spectrometry and multi-stage mass spectrometry for ultra-high-demand proteomics and drug research; introduces LXQ linear ion trap, and introduces Focus PolarisQ and new high-resolution magnetic mass spectrometry DFS

2006 Introduces the more sensitive Trace DSQTM II and the more cost-effective TSQ Quantum Access

2007 Launch of LCQ Fleet, LTQ XLTM, an innovative technology combining ETD electron transfer dissociation cracking source

2008 Introduced LTQ OrbitrapTM Series of High Resolution Mass Spectrometry Combined with Electron Transfer Dissociation ( ETD ) and Matrix Assisted Laser Desorption Ionization ( MALDI ) Capabilities

2011 Launched the world's first commercial hybrid quadrupole electrostatic field orbitrap mass spectrometer Q Exactive

2013 Introduces the world's first commercial 3-in-1 FusionTM TribridTM mass spectrometer and the new generation of high performance triple quadrupole liquid mass spectrometers TSQ Endura and TSQ Quantiva

Thermo Fisher Scientific Mass Spectrometry

From the mass spectrometer pioneer - Finnigan Mass Spectrometry, the industry's most complete line of mass spectrometry products. We are very willing to share with you 50 years of experience in the manufacture and use of scientific mass spectrometers, providing you with complete solutions for food safety regulatory testing and hazardous material screening.

Innovators and leaders in mass spectrometry

Customer Service Hotline, 400 650 5118

TraceFinderTM software developed for food safety monitoring

Mass spectrometry workstation integrating quantitative, screening and reporting functions

• Meets 21 CFR Part 11 requirements

• Process operation software integrating instrument control, method editing, data acquisition, automatic data processing and reporting

• Compatible with conventional resolution mass spectrometry and high resolution mass spectral data

• Quantitative testing of regulations and qualitative screening of food safety hazards

• Customer personalized report template

• Built-in mass spectrometry method and compound database for quantitative detection and screening of pesticides, veterinary drugs, additives, etc.

table of Contents

Pesticide residue analysis

Determination of pesticide residues and related chemicals in foods - Liquid chromatography - tandem mass spectrometry

Liquid chromatography-tandem mass spectrometry for quantitative analysis and qualitative determination of avermectin residues in foods containing more than 400 pesticide residues in foods by liquid chromatography-tandem mass spectrometry

Determination of benzoylurea pesticide residues in foods by liquid chromatography - tandem mass spectrometry

Determination of residues of carbendazim, imidacloprid, acetamiprid and thiophanate in fruits and vegetables by liquid chromatography-tandem mass spectrometry

Determination of 9 organophosphorus pesticide residues in plant-derived substrates - Liquid chromatography - tandem mass spectrometry

Determination of urethane residues in foods - Liquid chromatography - tandem mass spectrometry

Veterinary drug residue analysis

Determination of 26 β-agonist residues in foods of animal origin by liquid chromatography - tandem mass spectrometry

Determination of quinolone chemically synthesized antibiotics in foods by liquid chromatography - tandem mass spectrometry

Determination of nitrofuran-based chemical synthesis of antibiotics in foods - Determination by mass spectro

Determination of sulfonamide residues in foods of foods by liquid chromatography - tandem mass spectrometry

Determination of 8 macrolides and 2 lincosamide residues in foods of animal origin by liquid chromatography-tandem mass spectrometry

Determination of 9 penicillin residues in foods of animal origin by liquid chromatography - tandem mass spectrometry

Determination of residues of tetracyclines in foods of foods by liquid chromatography - tandem mass spectrometry

Determination of four nitroimidazoles and their metabolites in foods of foods by liquid chromatography - tandem mass spectrometry

Determination of malachite green and crystal violet and their metabolite residues in aquatic products and feeds by liquid chromatography - tandem mass spectrometry

Determination of methylene blue and its metabolite residues in aquatic products and feeds - Chromatography - tandem mass spectrometry

Determination of residues of benzimidazoles and worms - Liquid chromatography - tandem mass spectrometry

Determination of residual chloramphenicol - liquid chromatography - tandem mass spectrometry

Determination of triazine anticoccidial drug residues in foods of foods by liquid chromatography - tandem mass spectrometry

Determination of glucocorticoid residues in foods of foods by liquid chromatography - tandem mass spectrometry

Determination of androgen residues in foods of foods by liquid chromatography - tandem mass spectrometry

Biotoxin analysis

Determination of residues of mycotoxins in foods - Liquid chromatography - tandem mass spectrometry

TSQ Series Triple Quadrupole Mass Spectrometry and Regulatory Hazard Screening

appendix

Food safety analysis workflow

Thermo Scientific Life Science MS not only has a long tradition of technology, but also continues to innovate. Quadrupole mass analysis of true conjugate hyperboloids that fits the perfect theoretical electric field of a textbook is used on all TSQ® triple quadrupole mass spectrometers. Since launching the world's first triple quadrupole MS/MS (TSQ®) mass spectrometer in 1980, TSQ® triple quadrupole mass spectrometer has been widely used in environmental protection, agriculture, quarantine, food safety, etc. Analytical testing, fully capable of testing routine testing of large-volume samples of crops, livestock and poultry products, dairy products and related processed foods, such as pesticide residues in food, veterinary drug residues, mycotoxins, additives, nutritional supplements and organic pollutants And other projects to help you easily meet the increasingly stringent regulatory requirements.

TSQ® Triple Quadrupole Mass Spectrometer and Thermo Fisher Food Safety Testing Strategy