Author: Xu Click to view more of his autobiography
1. Global challenges and solutions
This week's "Science" (Science Vol 360, Issue 6390 , 18 May 2018) the focus of the journal due to excessive or long-term use of various antibiotics, pesticides and herbicides, lead, or will soon face without facing mankind The dilemma available for medicine. To this end, scientists have expressed their opinions and proposed various programs.
In "Abominable Evolution: Can we get rid of the sociobiology dilemma caused by insecticide resistance? The evidence presented in the article indicates that the evolution of insects and weeds exceeds the speed at which humans develop new chemicals. Therefore, the authors point out that ecological, genetic, economic, and socio-political factors must be put together for consideration, and there is hope to solve this problem.
The use of genomic techniques to analyze the emergence and spread of antibacterial pathogens is based on genome-wide sequencing (WGS) technology to reveal the inherent regularity of antimicrobial resistance (AMR) in bacterial pathogens in time and space. It is proposed to use this rule to more effectively use existing and future antimicrobial agents and to extend their life cycle.
Prospects for bioremediation and detoxification using biologics pin their hopes on the metabolic plasticity of prokaryotes and suggest that they can be used for bioremediation and environmental toxic substances, such as wastewater treatment to habitat restoration. .
The Global Challenges of Antifungal Drug Resistance to Human Health and Food Security also pointed out that in order to avoid the global collapse of the ability of humans to control fungal infections, we must strengthen the management of existing chemicals and accelerate new resistance. The development of fungal drugs and the use of emerging technologies to find alternative solutions.
2. What are the opportunities for NMT non-invasive micro-testing technology? ! Â
Summarizing the main arguments summarized above, nothing more than hopes for two aspects of comprehensive governance and screening for new technologies .
In the direction of comprehensive governance, scientists dream of the time and space evolution of resistance as the main breakthrough. As the author pointed out in the time and space from PC patch clamp to NMT non-damage micro-measurement technology (2) , the future development of scientific research will be carried out in different time and space dimensions. But the same as the author in the blog "Science" cancer immunotherapy is not unexpectedly frustrated: China's opportunity? Genomics alone cannot completely solve the physiological problems, which has been proven in the failure of humans to seek cancer switch genes for more than half a century.
Therefore, the non-invasive micro-testing technology can perform multi-time and multi-space exploration and detection in different spatial structures from organelles to organs and in the time range from seconds to hours. For scientists who are struggling with basic research in resistance, it is a shoal from the coast to the vast Pacific Ocean. For the engineers who developed the drug resistance application, the tool was undoubtedly changed from a small slab to a Liaoning ship.
In the screening of new technologies, when we look back at the process of the discovery of penicillin by British scientist Alexander Fleming in 1928, from the perspective of the killed bacteria, if they can speak, when there is penicillin, they It must be the expression below the cartoon, yelling. The NMT non-damage micro-test technology data on the right side will intuitively tell the researchers that our attempt is correct.
Now, let's review another definition of non-invasive micro-testing technology: NMT is a tool that detects the exchange of information between living organisms and the external environment through ion molecular velocity detection.
We know that non-invasive micro-testing technology can be detected in vivo from organelles to microorganisms, and the sensitivity of molecular flow velocity detection can reach femto (10 -15 moles â— cm -2 â— s -1 ), which is fully qualified for screening. Moreover, different ion molecular velocity maps will be more comprehensive, multi-time spatial dimension screening from signal conduction, energy metabolism, growth and development.
3. Why is China's opportunity?
Technical advantages:
China is currently the world's largest number of non-invasive micro-testing systems laboratories, and is the country with the largest number of non-injury micro-test technologies from research and development to technical support professionals. And over the past decade, we have accumulated a group of experts, professors and student groups in this field. Therefore, in terms of technology and talent, China has a first-mover advantage in the world.
Cultural advantage:
History is always amazingly coincidental and consistent. In the Western political zero-sum game day, when it was thin. Western science also seems to be difficult to jump out of the research ideas of non-friends and enemies. Although they also want to carry out 'integrated governance' 'biological control', it is clear that the Chinese have a natural advantage in this regard.
political advantage:
In today's intensive trade war, the state-owned large enterprises are being shut down by the sword, making the country aware of the importance of core technology. The basis of drug resistance and applied research, the importance of a country's security and people's life and health protection is self-evident!
Of course, challenges and opportunities will always coexist, and the application of non-invasive micro-testing technology in the field of drug resistance has just begun (see the literature below). But since we drove the aircraft carrier to the Pacific Ocean, we must only bravely move forward until we reach the other side of the victory!
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