Large-scale culture of anti-cancer dendritic cells
August 17, 2018 Source: Science and Technology Daily
Window._bd_share_config={ "common":{ "bdSnsKey":{ },"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":" 0","bdSize":"16"},"share":{ }};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')) .src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)];A team of researchers from the US and France published a paper in the Cell Report on the 14th that they have developed a method for large-scale cultivation of multiple types of dendritic cells, or a study that will promote the treatment of many types of cancer. .
Dendritic cells are professional antigen-presenting cells that efficiently ingest, process, and transmit antigenic information, and transmit perceived risk signals to lymphocytes to induce immune responses. Because dendritic cells are at the center of the human immune response, they are widely used in cancer treatment, especially cancer vaccine research. However, such cells are very rare in the human body, and the separation of them from the patient for the production of vaccines requires a very complicated method and is costly.
In the new study, the researchers found a new method for dendritic cell differentiation that uses human CD34+ precursor cells to mass produce plasmacytoid dendritic cells and two conventional dendritic cells—cDC1s and cDC2s. . Phenotypic, functional, and single-cell RNA sequencing analysis confirmed that these in vitro produced dendritic cells have strong homology to the corresponding cells in the blood.
The researchers also investigated the role of the Notch signal. The Notch signal is an important pathway for communication between adjacent cells to regulate cell development and plays a key role in biological development. This signal is critical for the production of a specific type of cDC1, which is considered to be the best dendritic cell type for cancer vaccines. The researchers found that some cancer treatments currently in clinical trials have defects that disrupt the notch signaling pathway, which may inhibit cDC1 and negatively affect the ability of the immune system to kill cancer cells.
The ability to large-scale culture of multiple types of dendritic cells in vitro is critical to the in-depth study of dendritic cell biology, helping scientists to better understand the role of this cell in the immune system. The researchers point out that because the immune response elicited by dendritic cells can target all types of cancer with limited side effects, their research is even more important. (Liu Haiying)
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