New drug delivery is expected to reduce cancer recurrence rate
February 22, 2018 Source: Xinhuanet
Window._bd_share_config={ "common":{ "bdSnsKey":{ },"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":" 0","bdSize":"16"},"share":{ }};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')) .src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)];A research team in the United States has developed a new mode of administration. By injecting a special gel, the chemotherapy and immunotherapy drugs are delivered to the tumor site and then released, which is expected to reduce the cancer recurrence rate.
In this study, the Guru team at the University of North Carolina in the United States treated melanoma and a breast cancer that had previously been less sensitive to immunotherapy based on animal models. The results showed that the treatment significantly reduced the cancer recurrence rate after the primary tumor of the mouse was removed. The research results were recently published in the journal Science and Translational Medicine.
The researchers said that the biocompatible polymer, when mixed with a cross-linking agent, immediately formed a gel in the body that carried the chemotherapy drug gemcitabine and an immunological checkpoint inhibitor.
The researchers explained that the gel first increases the concentration of active oxygen that occurs with tumor growth, allowing the immunotherapeutic to better recognize the tumor. Enriched reactive oxygen species cause the gel to gradually melt and release both drugs. Chemotherapy drugs kill some cancer cells first, which enhances the sensitivity of tumors to immunotherapeutics. As the gel degrades, the level of reactive oxygen species in the tumor site also decreases, which helps to inhibit tumor growth.
The author of the paper, Gu Yu, an associate professor at the University of North Carolina at Chapel Hill, told the media: "This is a simple method to incite the biological characteristics of the tumor and the body's own immunity to inhibit tumor development and reduce side effects while chemotherapy."
The researchers believe that this method may also be effective for other tumors. "There is still a lot of work to be done before entering the clinical trial, but I think this method has broad prospects," Gu said. (Reporter Zhou Zhou)
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