Anti-Ebola virus protein found in human cells helps develop small molecule drugs
December 18, 2018 Source: Science and Technology Daily Author: Liu Haiying
Window._bd_share_config={ "common":{ "bdSnsKey":{ },"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":" 0","bdSize":"16"},"share":{ }};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')) .src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)];US researchers recently published a paper in the journal Cell, saying that they found that a protein in human cells can help fight Ebola, and drugs that mimic the function of the protein may one day be effective in treating this deadly disease.
Like other viruses, Ebola viruses invade host cells and use them to replicate, but scientists still know very little about the specific pathways and details of virus intrusion during infection.
In a new study, Hult Quister of the Northwestern University's Fenberg Medical School collaborated with research partners at Georgia State University and the University of California at San Francisco to explore human proteins using affinity-labeled purification mass spectrometry (AP-MS). Interaction with Ebola virus proteins. Not only did they discover strong evidence of the interaction between the Ebola virus protein VP30 and the human protein RBBP6, but they also identified a 23 amino acid region in which RBBP6 binds to VP30. Further studies have shown that inhibition of RBBP6 stimulates viral transcription and accelerates Ebola virus replication; while stimulation of RBBP6 expression is more effective in inhibiting Ebola virus replication and preventing viral infection.
Hultquist pointed out that the virus will evolve to bypass the body's immune defenses, and human cells will in turn develop defense mechanisms against viruses. This evolutionary competition has been going on for a long time. The special defense mechanisms developed by humans have pointed out the direction for the development of targeted treatments. Their new research shows that targeted biologics have great potential for combating Ebola, and RBBP6-derived peptides are effective in inhibiting Ebola virus infection. Their ultimate goal is to develop a small molecule drug that can more easily enter human cells by mimicking the RBBP6 protein in response to the Ebola outbreak.
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