Japanese team successfully developed non-addictive analgesic compounds
September 10, 2018 Source: World Wide Web
Window._bd_share_config={ "common":{ "bdSnsKey":{ },"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":" 0","bdSize":"16"},"share":{ }};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')) .src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)];[Global Network Report] According to a report by the Japanese Kyodo News Agency on September 6, a team of Ms. Mukoulun, a lecturer at Wakayama Prefectural Medical University in Japan, announced on the 6th that it successfully developed the analgesic compound "AT-121". The advantage is said to be the absence of the addictive problem of opioid analgesics such as morphine, which will help to develop safe agents.
The team said that opioid analgesics are shown to bind to proteins on the cell membrane called "?-opioid receptors" to suppress the neural activity that transmits pain, to demonstrate effectiveness, but the effect is strong and will appear Harmful effects such as addiction and itching.
In the study, the team focused on the protein orphanin receptor on the cell membrane and synthesized AT-121, which binds to both receptors.
It is reported that the compound was administered to macaques and the results of the verification showed that the analgesic effect was about 100 times that of morphine, and it was not judged to have problems such as addiction and itching.
The team believes that AT-121 exerts a superimposed effect on both receptors, but because it has a mild effect on each receptor, it does not produce harmful effects.
Mukou said: "This will help to make use of the new mechanism of safe and non-addictive analgesics practical. International significance is also very large." (Reporter Wang Huan)
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