Release date: 2013-02-01
Recently, researchers at the Sanford-Bernham Medical Institute in the United States and Johns Hopkins University collaborated to develop cardiomyocytes from skin cells of a patient with hereditary heart disease and induced the heart in a culture dish. The disease model reproduces the main features of the disease. The researchers pointed out that this outcome helps people to better study the disease and test new treatments. Related papers were published in the January 27 issue of Nature. This hereditary heart disease is called arrhythmogenic right ventricular dysplasia/right ventricular cardiomyopathy (ARVD/C). Most patients with this condition have no symptoms before the age of 20, so it is difficult to study their progress and the corresponding treatment. Hui Shengwen, a senior author of the paper and associate professor of the Sanford-Bernham Institute of Medicine, said: "It is very difficult to prove the clinical relevance between the disease model in the culture dish and the disease in adult patients. ARVD/ The symptoms of C are usually manifested in adolescence, and the stem cells we use are embryos in nature. But our study has a key breakthrough in inducing embryonic cells to possess the metabolism of adult myocardium.†Researchers first from ARVD/C patients The skin cells are collected from the body and contain genetic variants associated with the disease; then some molecules are added to reverse the adult skin cells back to a similar embryo state, ie, to induce pluripotent stem cells (iPSCs); further induce iPSCs, It can supply patient-specific cardiomyocytes indefinitely. These cardiomyocytes possess most of the embryonic properties, but at the same time carry the patient's initial genetic variation. The ARVD/C cardiomyocytes in the embryonic stage of the culture dish showed no signs of any disease within one year. They used some mixture to induce the metabolism of cardiomyocytes to be converted from embryonic to adult. Metabolic maturation is the key to inducing embryonic cardiomyocytes to produce adult ARVD/C signals, because human fetal cardiomyocytes use glucose as the main source of energy, and adult cardiomyocytes use fat. They also found the characteristics of the ARVD/C heart in the mutagenized cardiomyocytes, a protein called PPAR that is overactive. The researchers pointed out that the new model reproduces the disease in culture dishes and provides a new potential drug target for the treatment of the disease. Daniel Garger, associate professor and medical director at the Johns Hopkins University School of Medicine's Center for Genetic Heart Diseases, said: "At present, there is no way to prevent the development of ARVD/C in the world. With this new model, we hope to A life-threatening disease that develops better treatments."
Source: Technology Daily
Whether it's from sleeping weird, working out too hard, or sitting hunched over for hours staring at your computer, most of us have dealt with kinks in our necks from time to time. According to a peer-reviewed article from Marco Funiciello and Zinovy Meyler, Doctors of Osteopathic Medicine, one of the best ways to soothe aches and pains in your neck is through massage therapy.
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