Research reports that wearable artificial kidneys are expected to replace dialysis machines.
More than 2 million patients with renal failure worldwide require long-term dialysis treatment. Patients undergoing dialysis treatment must strictly control their diet to ensure dialysis quality.
Studies have shown that long-term, high-frequency dialysis treatment is better, but the existing dialysis machines are non-portable instruments, limiting the patient's exercise and activities of daily living.
Dr. Jonathan Himmelfarb from the University of Washington said, “As a nephrologist, I hope that dialysis therapy will be significantly improved in the future – that is, it will improve the quality of life of patients, bring more autonomy and choice for patients to fully recover, and Extending the lives of patients. To this end, we should do our utmost to help patients achieve this ideal at an early date."
Himmelfarb and colleagues have developed a wearable artificial kidney that is continuously running. Early experimental studies have shown that the effective working time of artificial kidneys is 8 hours.
Currently, they applied the wearable artificial kidney to 11 patients with end-stage renal disease with an average dialysis time of 15 months, and reported a 24-hour treatment test.
During the normal operation of the instrument, a total of 5 patients completed 24 hours of treatment. One patient stopped treatment due to blood circulation clotting. Two patients had to replace the battery before the end of the 24-hour study. Three patients discontinued treatment during the study due to clearance of blood circuit bubbles.
The researcher JCI Insight reported that the research trial was terminated early due to technical problems related to the instrument.
During the period of treatment with artificial kidney, the subjects had no serious complications and were free to move. The patient indicated that the wearable artificial kidney had fewer side effects, the treatment was convenient and flexible, the treatment-related discomfort was less, and the activity was free and the overall satisfaction was satisfactory.
Researchers say that the device needs to be further designed and refined to address technical issues before conducting long-term research.
“We hope to conduct follow-up trials in the next few years,†said Dr. Himmelfarb. “It will take years of research to prove its effectiveness and safety before the instrument is applied to patients with kidney disease.â€
Dr. Karin Gerritsen and Dr. Jaap Joles from Utrecht University in the Netherlands have systematically reviewed the current research status of wearable artificial kidneys, saying that “wearable and portable artificial kidneys will be realized soon, but in It is still a long-term study before it is widely used in clinical practice. This equipment is a good choice for bedside hemodialysis patients every day (at night). Compared with the traditional three-week outpatient hemodialysis, the instrument has taken a big step forward. ."
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