Recently, the international academic journal Small published the high-Throughput Fabrication and Modular Assembly of 3D Heterogeneous Microscale Tissues in the field of micro-nano robotics and biomedical research in the micro-nano research group of the Shenyang Institute of Automation, Chinese Academy of Sciences. It was featured by ADVANCED SCIENCE NEWS with the title "New Method of Micro-Organization 3D Bio-Made" and ranked first in the number of news readings for several consecutive days.
The scientific research personnel of Shenyang Institute of Automation and experts in the field of life sciences have closely exchanged and cooperated in depth, actively combining robot technology with biomedicine, and strive to open up new application fields for robots in the field of new drug research and development. The field of biomedicine differs from traditional manufacturing in that its operational objects change from structured components to unstructured living cells, and the operating environment changes from normal atmosphere to physiological liquid environment. This is the perception, drive and control of robot technology. A lot of challenges. The micro-nano research group has actively explored the above problems, and has realized the manipulation of micro-tissues, cells and protein molecules under physiological environment, and provided key technical support for the application of robot technology in biomedicine.
Journal cover
This paper, published in the cover of Small, focuses on the demand for drug screening for the human micro-tissue environment. In the process of new drug development, drug toxicity and drug resistance testing is a crucial step. The existing single cell screening model has problems such as low efficacy and low toxicity detection. The main reason is that single cells are difficult to accurately simulate. Human environment. In response to the above problems, the research group proposed the Organ Real-time Assembly on Chip for micro-organizations, which enables online manufacturing of different types of three-dimensional cell micro-organisms according to requirements, and can simultaneously adopt micro-nano The robotic technology is assembled online, which forms a multi-cell complex tissue connector that is similar to the human physiological environment, and provides a feasible solution for in vitro simulation of human physiological environment. In addition, the whole process is realized by robotic automation method, so it has good repeatability and stability, thus ensuring the consistency of the human body physiological environment construction, laying a foundation for future tissue regeneration and personalized drug screening.
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