Recently, Dr. Stephen, a scientist from the University of California, published in the top magazine "Cell", saying that his team miraculously recorded close-range HD uncoded images reproduced by a single DNA molecule. It turns out that the model of human “dreaming†for more than half a century is full of mistakes. This discovery completely rewrites the biological knowledge we have learned in high school.
Traditionally, the DNA double helix structure is intertwined into four chains by four different bases. Under the conditions of the principle of base-complementary pairing, semi-reserved replication and semi-discontinuous replication, the enzymes such as helicase, DNA polymerase and ligase act on the chain structure, respectively, so that the newly generated genetic material and the mother are completely match.
The most characteristic of these is that the DNA polymerases located on the leader and lag chains coordinate to some extent to avoid mutations during unwinding.
The team's researchers extracted individual DNA molecules from E. coli and applied colorants. The scientists were shocked by the fact that real-time lenses showed real DNA. During the replication process, ligases did not coordinate with each other, but each single-stranded height. Independently copied, full of randomness, and finally able to perfectly match the parent chain!
In the lens, sometimes the lag chain stops running, but the leading chain continues to grow, and sometimes one of the chains suddenly starts to copy at 10 times normal speed, and there is no law to find! In addition, due to lack of coordination, DNA can even kick the helicase to pause replication, so that DNA polymerase can catch up.
This fact is enough to trigger a rethinking of the genetic stability of the scientific community! If the two chains operate independently, how do the untwisted DNA know to ensure that the replication process is carried out in an orderly manner? How to control the replication speed at a specific point in time to avoid genetic mutations? Life is really too mysterious, and perhaps humanity has a long way to go before the truth.
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