Vanity Fair columnist Nick Bilton recorded a blood test to see how Theranos drained his last drop of blood. Recently, the famous foreign community BuzzFeed once again threw a blockbuster - 23andMe, the genetic testing star company, announced that it will not carry out next-generation DNA sequencing. In September, an article in the journal Nature magazine entitled "The precision-oncology illusion" is directed at the precise treatment of tumors, such as the same as the light machine. From the big heat to the vomiting, is there any possibility of precision therapy? The author has sorted out the University of Toronto Dr. Ian F. Tannock and colleagues in the New England Journal of Medicine article "Limits to Personalized Cancer Medicine", hoping to find the answer.
What is precision therapy?
Precision therapy is also called personality therapy. Simply put, genetic sequencing is used to further understand cancer from molecular pathways. The use of tumor cell genomic mutations to distinguish tumors from normal tissues, to achieve targeted treatment of tumor cells, thereby achieving the purpose of prolonging the survival of patients and improving the quality of life of patients.
The speed of molecular pathology research and the comprehensiveness of diagnosis (from gene sequencing to expression profiling and proteomics) have encouraged investment institutions and cancer research centers to actively promote personalized cancer medicine. Precision therapy allows targeted administration of drugs through selective drug control. Today, targeted drugs have become an important part of cancer treatment, such as trastuzumab. Precision therapy has benefited some cancer patients, but for most patients with metastatic cancer, the benefit time is limited, especially in clinical roles.
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Pursuing independent research, inevitable waste of resources
In 2016, Obama allocated $215 million for the development of precision medicine, of which $0.7 billion was allocated to the National Cancer Research (NIC) to support personalized cancer medical clinical research in the cancer landing program. Almost all NCI-supported cancer research centers emphasize personalized medicine, and not only the National Cancer Center has related programs.
Most organizations pursue independent research and clinical programs. However, the results obtained in different project studies are mostly similar, which inevitably wastes resources, including patient resources, time of clinicians and scientists, and waste of funds. There are also groups that form alliances, such as the Lung Cancer Mutation Alliance, which consists of 16 lung pancreatic cancer multi-gene mutation detection agencies in the United States; and the UK Rectal Cancer Stratification Project, which has received $6.6 million in financing to provide colon cancer genome analysis for patients. . But this cooperation is rare. Fortunately, the US government's cancer lunar program offers more opportunities for collaboration.
Under ideal conditions, different cancer institutions emphasize different research approaches, so resources are applied to various fields. However, research funding is limited, and the waste of resources in personalized medical research may result in the deprivation of resources for other research.
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