Many diseases are often caused by multiple genes. Such as mental illness and metabolic diseases, but the interaction between genes is still unclear. There are also some malignant tumors that are often unstable and cause instability in the target and treatment outcomes. In addition, animal models that do not respond to many diseases, such as neurodegeneration, metabolic diseases, etc., have become more complicated in clinical human trials.
(Future symptomatic drugs will evolve into drugs for "genes")
Can human life expectancy reach 120 to 150? Will personalized medicine cure all diseases? Aaron Chehanovo, a winner of the Nobel Prize in Chemistry in 2004 and a foreign academician of the Chinese Academy of Sciences, recently proposed that the “third drug revolution†brought about by personalized medicine has already arrived, which will help humans cure more diseases, but they are facing The challenge cannot be ignored.
Reviewing the history of drug development, the first drug revolution represented by aspirin in the 1930s and 1960s was characterized by “accidental discoveryâ€; the second drug revolution from the 1970s to the end of the last century was characterized by “combination and screening of compoundsâ€. And personalized medicine based on modern genomics is opening the door to the third drug revolution.
Aaron Chehanovo said that the representatives of the third drug revolution will be targeted, personalized drugs. These drugs can target the gene-directed treatment of each person, making the treatment more precise and effective, with fewer side effects. “It seems that the same diseases and treatments may have different therapeutic effects for different patients. Because there are differences in individuals, age, gender, weight, etc. are different, not to mention the difference in genetics.â€
In the future, the right medicine will evolve into a drug for the “geneâ€. People can even target disease-causing genes and interfere with possible future diseases. By then, the era of "same disease with the same treatment" will come to an end. However, personalized medicine is still a long way forward. For example, Aaron Chehanovo says that many diseases are often caused by multiple genes. Such as mental illness and metabolic diseases, but the interaction between genes is still unclear. There are also some malignant tumors that are often unstable and cause instability in the target and treatment outcomes. In addition, animal models that do not respond to many diseases, such as neurodegeneration, metabolic diseases, etc., have become more complicated in clinical human trials.
From an economic point of view, the development of new drugs is expensive, and sometimes a drug development is as high as several billion dollars, which also leads to a future "DNA drug" audience will not be as extensive as the current "best-selling drugs." In addition, personalized medicine is also facing the question of bioethics. For example, people will worry that the pharmaceutical factory has mastered its own genome sequence, and personal life information security will not be guaranteed. However, personalized medicine based on genomics is still worth looking forward to. "The relationship between medical care and disease is a bit like 'a height of one foot and a height of one foot,' which is a long-term difference. But there is no doubt that personalized medicine will become a key key to human victory over disease." Aaron· Chehanovo said. I believe that everyone's expectation for a longer life will be realized soon.
(Source: Economic Daily)
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