An international team of researchers funded by the British Medical Research Council (MRC) identified three risk genes associated with Alzheimer's disease. The research results were published in the recently published "Nature-Transformed Psychiatry."
In order to find a genetic risk factor for diseases such as Alzheimer's disease, the commonly used method is to compare the DNA of the disease patient with a normal person to determine the genetic variation of the patient. At present, about 30 kinds of risk genes related to Alzheimer's disease have been discovered by this method. In the new study, a team led by researchers from the University of Edinburgh and the University of Queensland, Australia, used a technique to expand the sample population for genetic analysis.
The genetic information involved in the study was taken from the British Biobank, with a sample size of more than 300,000. Since most of them are too young to be diagnosed with Alzheimer's disease, the research team examined the medical information of their parents—many of whom suffer from Alzheimer's disease. The research team analyzed the above data in depth and combined the existing genetic information of 70,000 people (including Alzheimer's disease patients and non-patients), and finally discovered three new genes that may cause people to suffer from Alzheimer's disease.
This new discovery will help researchers better understand the mechanism of Alzheimer's disease and develop new treatments. Dr. Richard Marioni of the University of Edinburgh in the United Kingdom said: "New discoveries can provide key clues that relate to the biological processes of Alzheimer's disease. But the genetic combination is not the only risk factor for the disease. We are working to make people's genetics. Combining learning data with lifestyle information to more comprehensively and personally understand the risk of Alzheimer's disease and develop targeted risk reduction strategies to pave the way for the precise treatment of Alzheimer's disease Road." (Reporter Zheng Huanbin)
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