Release date: 2018-02-28
The discovery "opens up a whole new field of research," said Dr. Bimal Desai, principal investigator at the University of Virginia School of Medicine. "It has many aspects that will affect the clinical community."
Michael Schappe (left); Bimal Desai
Treatment nerve
Because of the presence of the blood-brain barrier, traditional neurological inflammation (such as Alzheimer's and Parkinson's) treatments are largely ineffective. The blood-brain barrier protects the brain from the dangers of bacteria or toxins in the blood and also blocks the treatment.
"Many of the drugs we use to treat inflammation now don't work in the brain because the brain doesn't let them pass," Desai explained in the Department of Pharmacology at Carter Immunology.
They have recently discovered that an important immune cell, macrophages (microglia), may be a viable breakthrough. Desai and his team have discovered a special electrical switch called a "calcium channel" in macrophages that does not cause inflammation without calcium cells. They used small molecules to target this switch, limiting macrophage calcium, and the results showed that it could prevent inflammation in the brain.
Better anti-inflammatory method
"Small molecules that reach the target (TRPM7 ion channel) are an affordable treatment option," said Michael Schappe, a graduate student at Desai Labs. "It has a lot of application scenarios, especially very nerve damage."
Desai pointed out that drug companies are developing drugs that target this type of switch, which may be good news for many patients with inflammatory diseases. "If you have arthritis or inflammatory bowel disease (IBD), you probably know that effective treatments are very expensive and can't be taken orally," he said. “Because they are biological products (protein molecules) that are difficult to produce and transport, a patient spends as much as $200 million a year on medication.†In the future, the price of this small molecule targeting ion channels will be very low and It works by oral administration.
Source: Biopass
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