According to a recent report by the Physicist Organization Network, chemists at the Scripps Research Institute in the United States have chemically modified the nucleotides of DNA to turn DNA into a platform for synthesizing new chemical substances. The study, published in the journal Applied Chemistry in Germany, demonstrates that DNA can not only store genetic information, but also develop pharmaceutical or nanomaterials.
DNA is modified and has the same replication function as normal DNA, and these unique properties make it an important raw material for synthetic Chemicals. The laboratory of the chemistry professor of the Scripps Institute, Freud Romsberg, has been concentrating on developing cutting-edge technologies for DNA modification for the past 10 years, hoping to eventually develop drugs, bioprobes and even artificial life forms. Last year, his lab published an important research in Nature Chemistry: the development of an artificial DNA polymerase (SFM4-3) that allows the use of fluorine or The methoxy modified DNA is replicated.
In this study, Romsberg Laboratories used Click Chemistry to introduce an azide into the nucleotides of DNA and demonstrated that SFM4-3 artificial polymerase allows azide-modified nucleotides. For replication, these modified DNA strands can also be exponentially amplified using polymerase chain reaction (PCR) techniques. Azide can form chemical bonds with many other molecules, so the introduction of fluorescent molecules or biotin molecules into azide-modified DNA can produce various functional DNAs.
For example, they use azide-modified DNA as the center, and closely bind a variety of DNA strands to form a "wash bottle brush" structure, and then obtain a DNA network by PCR amplification. A new gel with a wide range of uses. Tests have shown that proteins encapsulated in gels retain their biochemical activity, so DNA gels can be used to deliver drugs or to develop three-dimensional cells.
Romsberg said that they also successfully used SFM4-3 to replicate and amplify DNA modified by chlorine, amino and hydroxyl groups, respectively. They will next test the replication of this artificial polymerase with other modified DNA, and use these modified DNA to synthesize new materials with specific uses such as gels. (Technology Daily)
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