Scientists have found that the oncogene STAT3 can also suppress cancer? !

IL-6 is an important cytokine that plays an important role in regulating cell survival and tumor growth. Highly active IL-6 promotes tumor growth, and STAT3 is an important effector downstream, acting as an oncogene in many types of cancer. There are a number of therapeutic approaches that target the inhibition of IL-6 and STAT3 for cancer therapy.

However, according to the results of this study, the role of IL-6 and STAT3 in prostate cancer is somewhat different from previous understanding. The researchers found that activated STAT3 activates the ARF gene and blocks in prostate cancer cells. Cell division in turn inhibits cell growth.

In this study, the researchers suppressed STAT3 or IL-6 signaling at the genetic level in a mouse model of Pten-deficient prostate cancer, and found that inactivation of this signaling pathway accelerates cancer progression and leads to cancer metastasis. They found that p19ARF is a direct target of STAT3, and deletion of the STAT3 signaling pathway disrupts the ARF-Mdm2-p53 tumor suppressor axis, but does not affect cell senescence. In addition, the researchers also found STAT3 and CDKN2A mutations in human prostate cancer cells, and STAT3 and CDKN2A deletion mutations occur frequently in metastatic prostate cancer cells.

The researchers also found that STAT3 and p14ARF deletions in patients with prostate tumors were significantly associated with an increased risk of prostate cancer recurrence and metastasis. Therefore, the expression levels of STAT3 and ARF can be used as diagnostic markers to distinguish the risk of prostate cancer.

Collectively, this study found that STAT3, which plays an oncogene role in other types of cancer, plays a tumor suppressor role in prostate cancer, and this tumor suppressor effect affects ARF-Mdm2-p53 tumor suppression by regulating ARF expression. The role of the factor axis is achieved. The expression levels of STAT3 and ARF may be used to predict prostate cancer risk and may be further developed and applied.

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