Release date: 2015-06-12
Recently, Tianjin Cancer Hospital achieved breakthroughs in the treatment of children with Hodgkin's lymphoma. The hospital successfully treated a child with relapsed and refractory Hodgkin's lymphoma by implementing the "myeloablative allogeneic hematopoietic stem cell transplantation" technique. This type of case has not been reported in the treatment of domestic Hodgkin's lymphoma, opening a new way for the treatment of blood tumors.
The patient was only 11 years old and was diagnosed with Hodgkin's lymphoma in 2011. After 6 cycles of chemotherapy in the local area, he came to Tianjin Cancer Hospital for treatment in 2014 due to recurrence of the disease. He was diagnosed with recurrent refractory Hodgkin's lymphoma of the neck.
Taking into account the patient's disease characteristics and the requirements of the patient's family, Tianjin Cancer Hospital adopted the "myeloablative allogeneic hematopoietic stem cell transplantation" treatment program, successfully adopted the patient's sister stem cells for successful matching, and developed individualized marrow for the patient. Sexual pretreatment program. Advanced treatment with high-intensity chemotherapy, and the addition of anti-tumor drugs, under the premise of ensuring the successful implantation of donor hematopoietic stem cells, to maximize the removal of residual tumor cells in vivo, completely reduce the probability of tumor recurrence. The stem cell reinfusion process uses a combination of infusion of bone marrow stem cells and peripheral blood stem cells to ensure that hematopoietic stem cells can be implanted faster and to minimize malignant rejection.
After nearly one month of careful treatment, the patient successfully completed the allogeneic hematopoietic stem cell transplantation through the three principles of clear marrow preconditioning, hematopoietic stem cell reinfusion, and anti-rejection. After more than two months of late observation and treatment, the patient has now successfully passed the period of myelosuppression, no serious infection and bleeding, white blood cells returned to normal levels, immune and hematopoietic function were all reconstructed, and treatment was successful.
Source: Technology Daily
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