Researchers from Washington University in St. Louis have developed a new test technology that detects almost all known viruses that infect humans and animals. This test helps doctors diagnose infections, regardless of whether they have relevant clues.
It is understood that the accuracy of this test, named ViroCap, still requires clinical trials and may take several years to be used on patients. However, the technology being developed has been provided to health care providers and related researchers.
So far, we have discovered thousands of viruses that cause human and animal diseases, making it increasingly difficult for doctors to diagnose, and sometimes a series of different tests. Now, the available tests are not sensitive enough to detect suspected viruses suspected of causing disease in patients and cannot detect low levels of viruses.
ViroCap differs from other tests in that doctors don't need to know what they are looking for. Pediatric professor Gregory Storch says that when a disease outbreak is still unknown or difficult to find after standard testing, this The new test technology will be especially useful.
The research team of this test published the final research results in the September 22, 2015, Genomics Study, for their study, 14 patients who were examined by VigorCap and his colleagues on the ViroCap test. Stool, blood, and nasal secretions were evaluated.
Standard tests can only detect viruses in 10 patients and fail to detect common viruses such as influenza B and herpes viruses. The new ViroCap test technology found viruses that were missed in early genome sequencing tests in the remaining four patients.
Pediatric lecturer Todd Wylie said: "This test is very sensitive, it can even detect virus variants that are closely related to the gene." At present, the slight genetic variation of the virus is often not able to be distinguished in detail using the currently available tests. It complicates the ability of doctors to detect all variant viruses.
In another group of eight children who developed fever for unknown reasons, 11 tests were detected in the standard test, and ViroCap successfully found another 7 viruses, including one that is usually harmless but can cause serious problems. Infected respiratory virus. The number of viruses detected in these two groups increased from 21 to 32, or the number soared by 52%.
The researchers wrote in the research report: "We have worn a capture panel of the target sequence designed to collect nucleic acids from DNA and RNA viruses that infect vertebrate hosts. ViroCap can dramatically improve metagenomic sequencing (MSS) and has Applied to both words and clinical utility."
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